Bio-Med Ideas

January 21, 2018

Molecular therapy for inflammation and arthritis: Simvastatin (brand name: Zocor), a lipid-lowering medication,  increases IL-9 levels, augments proliferation of ILC2s (type 2 innate lymphoid cells) and regulatory T (Treg) cells, promotes resolution of inflammation, attenuates cartilage destruction, decreases bone loss, and inhibits pathological features associated with arthritis via up-regulation of its target genes, 21/January/2017, 10.43 pm

Introduction: What they say A study from Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich Alexander University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany shows that […]
January 21, 2018

Molecular therapy for tuberculosis: Tadalafil, a drug used in the treatment of erectile dysfunction and pulmonary arterial hypertension, deacetylates RelA/p65, inhibits inflammatory gene expression downstream of RelA/p65, inhibits TB pathogenesis, increases the efficacy of anti-TB drug, and promotes M. tuberculosis clearance via up regulation of its target gene, 21/January/2017, 10.34 am

Introduction: What they say: A study from the Singapore Immunology Network, Agency for Science, Technology and Research, Singapore; and Lee Kong Chian School of Medicine, Nanyang […]
January 20, 2018

Molecular therapy for pulmonary arterial hypertension: Tadalafil [Brand name: Cialis, Adcirca and others], a cGMP-specific phosphodiestrase type 5 inhibitor used in the treatment of erectile dysfunction and pulmonary arterial hypertension, inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 20/January/2018, 11.33 pm

What they say:  A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published, in the 15 November  2009 issue of the journal “Nature Medicine”[the number […]
January 20, 2018

Molecular therapy for tuberculosis: Sildenafil, a drug used in the treatment of erectile dysfunction and pulmonary arterial hypertension, deacetylates RelA/p65, inhibits inflammatory gene expression downstream of RelA/p65, inhibits TB pathogenesis, increases the efficacy of anti-TB drug, and promotes M. tuberculosis clearance via up regulation of its target gene, 20/January/2018, 11.26  pm

Introduction: What they say: A study from the Singapore Immunology Network, Agency for Science, Technology and Research, Singapore; and Lee Kong Chian School of Medicine, Nanyang […]
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