Bio-Med Ideas

December 19, 2017

Natural product-derived PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy in Glioblastoma: A therapeutic mix encompassing Macbecin, Temozolomide, EGCG, Salinomycin, Fluvastatin, Forodesine and Chloroquine (MTESFFC) inhibits oncoproteins EGFR, and Bcl-xl expression, increases tumor suppressor p53 expression, inhibits glioblastoma proliferation, increases interferon-IFNγ signalling, increase antigen presentation and unfolding response, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 19/December/2017, 10.02 pm

Introduction:What they say: A recent study from Department of Molecular and Medical Pharmacology, David Geffen UCLA School of Medicine, Los Angeles, California, USA; Jonsson Comprehensive Cancer […]
December 17, 2017

Vitamin-based Lifespan extension therapy: Pyridoxamine (PM), a form of Vitamin B (6),  increases life span via up-regulation of its target gene BubR1, 17/December/2017, 11.51 pm

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and […]
December 17, 2017

Natural product therapy for pulmonary arterial hypertension: Glycyrrhetinic acid, isolated from Licorice, inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 17/December/2017, 11.42 pm

What they say:  A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published, in the 15 November  2009 issue of the journal “Nature Medicine”[the […]
December 17, 2017

Molecular therapy for Cardiomyopathy: A pharmaceutical mixture (PMSFN) encompassing  Pyridoxamin (PM) and Sulphoraphane (SFN) decreases the expression of Sox6, restores the balance between slow- and fast-twitch myofiber proteins and alleviates Cardiomyopathy via up regulation of its target gene, 17/December/2017,  11.03 pm

Introduction: What they say   A study from the Department of Cardiology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA; and Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA shows that “Trbp regulates heart […]
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