Bio-Med Ideas

September 21, 2017

PD-1 pathway activation for Pain therapy: Fluoxetine, the widely used drug in the treatment of depression, mood disorders among others,  increases the expression of PD-L1, attenuates acutes and chronic pain, suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gen, 21/September/2017, 10.30  pm

Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]
September 21, 2017

Natural product therapy for pulmonary arterial hypertension: Salvianolic acid A  inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 21/September/2017, 10.22 pm

What they say:  A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November  2009 issue of the journal “Nature Medicine”[the […]
September 20, 2017

Natural product-based combinatorial therapy for Lifespan extension: A therapeutic mix encompassing Cholecalciferol , Astaxanthin, DIM, and Lutein (CADL) activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, alleviates ageing feature and extends lifespan via up regulation of its target gene ATG5 (Autophagy related 5), 21/September/2017, 1.55 am

Introduction: What they say A study from the Global Research Laboratory, Seoul National University, Korea shows that “Overexpression of Atg5 in mice activates autophagy and extends lifespan.” This study was […]
September 20, 2017

Natural product-derived CDK4/6 pathway blockade enhances the efficacy of Cancer immunotherapy: A pharmacological mixture encompassing Pravastatin, Metformin, Gedunin, Nexturastat, PEITC, & Linalool (PMGNPLF)  inhibits the expression of cell cycle protein CDK4/CDK6, increases levels of T-III IFNs, inhibits the proliferation of Treg cells, decreases DNMT1 expression, inhibits the expression of a number of immune evasion molecules, increases antigen presentation and unfolding response, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target genes, 21/September/2017, 1.53 am

Introduction:What they say: A recent study from Division of Molecular Oncology & Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands has identified […]
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