Bio-Med Ideas

May 18, 2017

Natural product-derived Life-extension therapy: Puerarin, isolated from Pueraria lobata (Kudzu) and Pueraria montana, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 18/May/2017, 7.13 am

What they say: A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal […]
May 18, 2017

Natural product therapy for middle aged TIIDM patients: Methyl Jasmonate, isolated from Jasmine and Mulberry (Morus nigra), decreases DNA-PPK expression, suppresses phosphorylation of HSP90a, increases AMPK activity, augments mitochondrial biogenesis and energy metabolism, promotes weight loss and exercise endurance and alleviates TIIDM via down regulation of its target gene, 18/May/2017, 7.10 am

Introduction: What they say A study from the Laboratory of Obesity and Aging Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD […]
May 17, 2017

Natural product-derived therapy for EVI-1-Overexpressing Acute Myeloid Leukemia: Celastrol, isolated from Thunder God Vine, decreases the expression of MECOM/EVI-1 and its down target genes, including CKMT-1, alters Arginine-creatine metabolism, inhibits mitochondrial respiration, depletes ATP levels, and promotes regression of EVI-1-overexpressing AML via up regulation of its target gene, 18/May/2017, 7.04 am

Introduction: What they say: A study from the Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA; […]
May 16, 2017

Laminar shear stress-based therapy for TIIDM and obesity-associated metabolic deficits: Laminar shear stress increases Lipocalin 2 (LCN2) expression, activates an MC4R-dependent anorexigenic pathway, suppresses appetite and weight gain, increases insulin secretion, improves glucose tolerance, promotes glucose homeostasis, improves obesity-associated metabolic deficits and prevents progression to TIIDM via down regulation of its target gene, 17/May/2017, 12.08 am

Introduction: What they say A study from the Department of Physiology-Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York, USA shows that […]
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