Bio-Med Ideas

May 29, 2017

Natural product-derived therapy for Metastatic cancers: Dihydromyricetin (DHM), found in Ampeopsis Grossdentatam, decreases the expression of metastasis promoters ZBTB2 and PPM1F, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 26/May/2017, 12.04 am

From Significance of the study to Public health relevance: Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more […]
May 29, 2017

Natural product-derived therapy for Chronic Myeloid leukaemia (CML): Honokiol, isolated from Magnolia Grandiflora (MG), decreases the expression of Musashi2, inhibits cytosolic aminotransferase BCAT1 expression, decreases the intracellular production of BCAAs (Branched-chain amino acids), increases the expression of tumor suppressor genes, promotes differentiation of CML cells, and inhibits cancer progression in Myeloid leukemia via up-regulation of its target gene, 29/May/2017, 11.43 pm

Introduction: What they say: A study from the Department of Biochemistry-Molecular Biology, Franklin College of Arts and Sciences, The University of Georgia, Athens, Georgia 30602, USA; […]
May 29, 2017

Natural product-derived therapy therapy for Stroke: Oleuropein aglycone, isolated from Olive oil, attenuates hippocampal neurons injury, and ameliorates stroke damage and neurological deficits via up regulation of its target gene BDNF, 29/May/2017, 10.40 pm

Introduction: What they say A recent study from Research Center for Neurobiology and Department of Neurobiology, Xuzhou Medical College, 209 Tongshan Road, Xuzhou, Jiangsu 221004, PR China; […]
May 28, 2017

Laminar shear stress-based therapy for Diabetic nephropathy (DN): Laminar flow-induced shear stress increases Pyruvate kinase M2 (PKM2) expression, decreases toxic glucose metabolites, mitochondrial dysfunction and apoptosis, augments glycolytic flux and PGC-1α levels, improves metabolic abnormalities, albuminuria, glomerular pathology, and renal dysfunction and alleviates diabetic nephropathy via down regulation of its target gene, 29/May/2017, 12.24 am

Introduction: What they say A study from the Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA shows that “Pyruvate kinase M2 activation may […]
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