Bio-Med Ideas

March 29, 2017

Natural product-derived therapy for glucose homeostasis and TIIDM: Polydatin (PD), a longevity-promoting molecule isolated from Polygonum cuspidatum, inhibits Amysin expression, increases insulin secretion, and decreases the risk of hyperglycemia via down regulation of its target gene Sox4, 29/March/2017, 11.06 pm

Introduction: What they say Nobel laureate in Physiology/Medicine (1975) Prof. David Baltimore and his research team, from California Institute of Technology, California, USA, had reported in […]
March 29, 2017

Natural product-derived therapy for Myocardial Infarction: Salvianolic acid B, isolated from Salvia Miltiorrhiza Bge, inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up regulation of PNUTS, 29/March/2017, 11.11 am

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, […]
March 29, 2017

Natural product-derived Life-extension therapy: Cryptotanshinone (CPT), found in Salvia miltiorrhiza Bunge, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 29/March/2017, 7.54 am

What they say: A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal […]
March 28, 2017

Natural product-derived PD-1 pathway blockade for Human cancer therapy: Salvianolic acid A, one of the main components of Salvia Miltiorrhiza Bge, decreases the activity of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 29/March/2017,4.53 am

Introduction:What they say:  A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK […]
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