Bio-Med Ideas

February 11, 2017

Natural product-derived PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: Paeonol (2′-hydroxy-4′-methoxy Acetophenone), isolated from Paeonia Suffruticosa Andrews, inhibits the expression of PD-L1, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 11/February/2017, 6.50 am

Introduction:What they say: A recent study from Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, […]
February 11, 2017

Natural product-derived therapy for Myocardial Infarction: Rice bran protein hydrolysates (RBPs) inhibit DNA damage responses, induce telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 11/February/2017, 6.37 am

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, […]
February 11, 2017

Anti-telomerase cancer therapy: Calycosin, the major bioactive isoflavonoid in the dry root extract of Radix astragali, suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and the cellular immortality gene telomerase and inhibits cancer progression via down-regulation of it target gene, 11/February/2017, 5.58 am

Introduction: What they say:   The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 issue of the Nature journal (492(7428):285-9; and I.F: >42) stating that “The TEL […]
February 10, 2017

Natural product-derived therapy for glucose homeostasis and TIIDM: Rice bran protein hydrolysates (RBPs) increase Pax6 and insulin expression, decrease the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improve insulin sensitivity, promote glucose homeostasis and prevents progression to TIIDM via down regulation of their target gene, 10/February/2017, 11.22 pm

Introduction: What they say  A study from the Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, […]
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