Bio-Med Ideas

February 4, 2017
Published by admin_auro at February 4, 2017
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Natural product-derived therapy for Human Leukemias: Casuarinin, a hydrolyzable tannin isolated from the bark of Terminalia arjuna Linn. (Combretaceae), suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 4/February/2017, 7.20 am

Introduction: What they say Noble laureate in Physiology/Medicine (1975) Prof. David Baltimore, from California Institute of Technology, California, USA, had reported in the July 8, 2014 issue of the Journal “Blood” that: “Dual mechanisms […]
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February 4, 2017
Published by admin_auro at February 4, 2017
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Anti-telomerase cancer therapy: Gastrokine-1 suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and the cellular immortality gene telomerase and inhibits cancer progression via down-regulation of it target gene, 4/February/2017, 6.33 am

Introduction: What they say:   The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 issue of the Nature journal (492(7428):285-9; and I.F: >42) stating that “The TEL […]
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February 3, 2017
Published by admin_auro at February 3, 2017
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Natural product-based Lifespan extension therapy: Piper betle leaf (PBLs) prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 3/February/2017, 11.36 pm

Significance of the study: It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown […]
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February 3, 2017
Published by admin_auro at February 3, 2017
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Small molecule-based PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: Genistein, found in Soy and Amur (Maackia amurensis) among others, inhibits the expression of PD-L1, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 3/January/2017, 11.23 pm

Introduction:What they say: A recent study from Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, […]
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