Bio-Med Ideas

January 13, 2019

Natural-product-based combinatorial therapy for Lifespan extension: A therapeutic mix encompassing Fasudil, Catalpol, Ursolic acid, Isoliquiritigenin, Maresin, DIM, Ursolic acid  Lutein, Maresin, Cholecalciferol (FCUIMDULMC) activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, alleviates ageing feature and extends lifespan via upregulation of its target gene ATG5 (Autophagy-related 5), 13/January/2018, 10.03 am

Introduction: What they say A study from the Global Research Laboratory, Seoul National University, Korea shows that “Overexpression of Atg5 in mice activates autophagy and extends lifespan.” This study was […]
January 12, 2019

Unexpected gain of taking pain medication: Pain medication may extend healthspan and lifespan: Celecoxib (trade name: Celebrex, Onsenal),  a nonsteroidal anti-inflammatory drug (NSAID) used to treat osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute pain and others, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, via up regulation of its target gene, 12/January/2018, 10.52 pm

What they say?  A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal […]
January 12, 2019

Ribonucleic acid-based therapy for diabetes: LncRNA PVT1-214 increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state, via up-regulation of  its target gene Lin28, 12/January/2019, 8.37 am

Introduction: What they say:   A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis […]
January 12, 2019

Repurposing the anti-hyperglycemic drug Pioglitazone into an anti-pulmonary arterial hypertension drug: Pioglitazone (brand name: Actos) inhibits the development of pulmonary arterial hypertension (PAH) via down-regulation of its target gene Notch3, 12/January/2019, 8.23 am

What they say:  A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published, in the 15 November  2009 issue of the journal “Nature Medicine“[the number […]
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