Bio-Med Ideas

December 6, 2016

Molecular therapy for Myocardial Infarction: Amiodarone, a second line agent in the treatment of cardiac arrest, inhibits DNA damage responses, increases telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 6/December/2016, 3.20 pm

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, […]
December 6, 2016

MiRNA-based PD-1 pathway blockade for Human cancer therapy: MiR-940 decreases the expression of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 6/December/2016, 12.46 pm

Introduction:What they say:  A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK […]
December 5, 2016

Natural product-based Lifespan extension therapy: Apple extract increases the expression of longevity-promoting and antiaging gene Klotho via up regulation of its target gene, 5/December/2016, 11. 33 pm

What is known? It has been shown earlier that Klotho: (1) extends the lifespan of mice by about 19-31%; and (2) increases cognition.  From Significance of […]
December 5, 2016

Natural product-derived therapy for brain repair and Lifespan extension: Shikonin, found in Zicao (also known as purple gromwell), increases VGF and BDNF expression, promotes Oligodendrocytes (OP) proliferation, triggers myelination on neurons, reverts neural damage, produces antidepressant like effects, and prolongs lifespan via up-regulation of its target gene, 5/December/2016, 10.52 pm

What they say: Introduction:   A recent study from the Department of Biochemistry & Molecular Pharmacology, Smilow Research Center, Howard Hughes Medical Institute, NYU School of […]
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