Bio-Med Ideas

October 5, 2016
Published by admin_auro at October 5, 2016
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Natural product Anti-telomerase cancer therapy: Honokiol, a bioactive constituent of Magnolia-grandiflora/dealbata/obovata/officinalis, suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down regulation of its target gene, 5/October/2016, 10.00 am

The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 Nature (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.”  This […]
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October 5, 2016
Published by admin_auro at October 5, 2016
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Therapeutic insights into “awakening the sleeping angel” in mutant p53-expressing human tumors: MiR-497 increases the expression of tumor suppressor p53 homologue TAp63γ and induces regression of p53-mutated human tumors via down regulation of its target gene, 5/October/2016, 8.14 am

Significance: Cancer suppressor p53 is mutated in more than 50% of human cancers of different origin, while its pathway is altered in about 80% of tumors. […]
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October 5, 2016
Published by admin_auro at October 5, 2016
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Molecular therapy for Myocardial Infarction: JunB improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 5/October/2016, 7.38 am

A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. On […]
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October 4, 2016
Published by admin_auro at October 4, 2016
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Therapeutic insights into PD-1 pathway blockade for Human cancer therapy: Olea europaea leaf extract (OLE) inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down regulation of its target gene, 4/October/2016, 10.35 pm

A recent study from Division of Infectious Diseases, School of Medicine, Johns Hopkins University, Baltimore, MD 21218, United States shows that “TGF-β1-Mediated Smad3 Enhances PD-1 Expression […]
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