Bio-Med Ideas

November 18, 2016
Published by admin_auro at November 18, 2016
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Life-extension therapy: Ossotide, a chemical compound known to promote bone formation, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 18/November/2016, 10.42 pm

What they say? A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows […]
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November 18, 2016
Published by admin_auro at November 18, 2016
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Small Molecule therapy for glucose homeostasis and TIIDM: PGE2 (Prostaglandin-E2/ dinoprostone) increases IKKß and XBP1s activity, decreases the levels of tumor suppressor/stress-responsive proteins, such as PDCD4, and PTEN, reduces ER stress, improves insulin sensitivity, promotes glucose homeostasis and prevents the progression of TIIDM via up regulation of its target gene, 18/November/2015, 10.14 pm

What they say:  A study from the Division of Endocrinology, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02130, USA; Laboratory of Gene Regulation and Signal […]
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November 18, 2016
Published by admin_auro at November 18, 2016
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Natural product-based PD-1 pathway blockade for Human cancer therapy: Eriocitrin, found in lemons , decreases the expression of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 12.58 pm

Introduction:What they say:  A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK […]
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November 18, 2016
Published by admin_auro at November 18, 2016
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Anti-metastasis therapy: MiRNA-9600 increases the expression of TPM1 (tropomyosin) and inhibits migration and invasion of metastatic cancer cells via down regulation of its target gene, 18/November/2015, 11.41 pm

Research findings to Therapeutic opportunity:  The study presented here suggests that MiRNA-9600, by decreasing the expression of its target genes, it may increase the expression of TPM1 (tropomyosin). […]
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