Bio-Med Ideas

October 11, 2016
Published by admin_auro at October 11, 2016
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Natural product anti-inflammatory therapy for upper respiratory tract inflammatory diseases: Fiestin, isolated from Strawberry, increases the expression of negative regulator of inflammation MyD88(s), inhibits pro-inflammatory mediators in lungs, and alleviates the common respiratory pathogen nontypeable Haemophilus influenzae (NTHi)-exacerbated asthma & chronic obstructive pulmonary disease via up-regulation of its target gene, 11/October/2015, 11.20 pm

A study from the Center for Inflammation, Immunity &Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, 30303, USA shows that: “Resveratrol suppresses NTHi-induced inflammation […]
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October 11, 2016
Published by admin_auro at October 11, 2016
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Natural product therapy for KRAS-mutant lung cancer: α-Lipoic acid decreases the expression of XPO1, increases the level of NFKBIA, inhibits NFKB transcriptional activity and suppresses the progression of KRAS-mutant lung cancer via up regulation of its target gene, 11/October/2016, 11.08 pm

A recent study from the Department of Cell Biology, University of Texas Southwestern Medical Center, Texas 75390, USA shows that XPO1 can be pharmacologically targeted in KRAS-mutant lung […]
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October 11, 2016
Published by admin_auro at October 11, 2016
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Natural product Anti-telomerase cancer therapy: Withaferin A (WFA), a natural compound derived from Withania somnifera, suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down regulation of its target gene, 11/October/2016, 10.48 pm

The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 Nature (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.”  This […]
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October 11, 2016
Published by admin_auro at October 11, 2016
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Natural product-based cancer therapy: γ-Bisabolene, one of the main components of Cardamom, inhibits cancer development by suppressing the expression of nucleotide sanitizing enzyme MTH1/NUDT1, 11/October/2016, 10.15 pm

A study from Karolinska Institutet, Stockholm, Sweden shows that “MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.” This study was published in the April 10, 2014 Nature [I.F >42] by Prof. Thomas […]
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