A recent study from University of Chicago (Illinois, USA) shows that “SPOP Promotes Tumorigenesis by Acting as a Key Regulatory Hub…” This study was published in the prestigious Journal Cancer Cell (One of the high profile journals in cancer biology with an I.F of 24.755) by Prof White KP, Dr Li G and others from the Institute for Genomics and Systems Biology, University of Chicago and Argonne National Laboratory, Chicago, Illinois (IL).
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Insights into mechanisms that dysregulate tumor suppressor networks in human cancer cells: The reprogramming protein Oct-4 increases the expression of oncogenic protein SPOP via down regulation of its target gene. This study may unveil how the stem cell protein Oct-4 dismantles tumor suppressor network in human cancers.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Insights into mechanisms that dysregulate tumor suppressor networks in human cancer cells: The reprogramming protein Oct-4 increases the expression of oncogenic protein SPOP via down regulation of its target gene, 27/June/2014, 6.01 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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