Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, Insights into the regulation of Stress-induced Hb synthesis: Stress-induced hormone ACTH increases fetal HbF levels via down regulation of its target gene, 23/September/2014, 07.04 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Web: http://genomediscovery.org
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Significance: This study suggests that ACTH, by down regulating the expression of its target gene, it may increase the levels of HbF. Thus, pharmacological formulations encompassing “ACTH activator” may be used to treat: (1) Sickle cell disease ; (2) β-thalassemias; and (3) disease conditions that has lower levels of HbF.
* Research cooperation
