A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the March 7 2013 Nature by Prof Dimmler, Boon, and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Insights into the treatment of alcohol-induced cardiac ageing: Heavy alcohol drinking inhibits myocardial function and promotes myocardial infarction via up regulation of its target gene. By limiting the intake of alcohol, one may prevent ageing/stress-associated decline in cardiac function. Together, this study suggests that pharmacological formulations encompassing “compounds that inhibit Alcohol-induced target genes” may be used to improve cardiac function in heavy drinkers.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, Insights into the treatment of alcohol-induced cardiac ageing: Heavy alcohol drinking inhibits myocardial function and promotes myocardial infarction via up regulation of its target gene, 23August/2014, 05.44 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Significance: This study elucidates the mechanism by which Alcohol declines myocardial function. Furthermore, this study suggests, for the first time, small molecule compounds that inhibit Alcohol-induced target gene expression may be used to treat alcoholics suffering from various myocardial disorders, including myocardial infarction.