Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Citation: Boominathan, Insights into the treatment of Fibrosis: Tumor suppressor BMP4 suppresses the expression of TGFß receptor II (TGFBR2) and extracellular matrix proteins via up regulation of its target gene, 23/October/2014, 14.43, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Significance: This study suggests that BMP4, by increasing the expression of its target gene, it may suppress the expression of TGFß receptor II (TGFBR2) and extracellular matrix proteins. Thus, pharmacological formulations encompassing “BMP4 activators“ may be used to treat fibrosis.
Amount: $300
Undisclosed information: A detailed mechanistic insight into how BMP4 suppresses the expression of TGFß receptor II (TGFBR2) and extracellular matrix proteins.
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