A study from Department of Anesthesiology and Center for Shock, Trauma, and Anesthesiology Research, University of Maryland School of Medicine, USA has reported that “Downregulation of miR-23a and miR-27a following Experimental Traumatic Brain Injury Induces Neuronal Cell Death through Activation of Proapoptotic Bcl-2 Proteins.” This study was published in the 23 July 2014 Journal of Neuroscience by Sabirzhanov B and others (2014).
On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: Insights into the treatment of traumatic brain injury (TBI): Acrolein, a natural product isolated from areca nut, promotes neuronal survival and protects from traumatic brain injury via up regulation of its target gene. This study suggests that acrolein, by up regulating its target gene, it may suppress the expression of Proapoptotic Bcl-2 Proteins, thereby promoting neuronal survival. Together, this study suggests that pharmacological formulations encompassing “acrolein or its derivates“ can be used to treat traumatic brain injury (TBI).
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Insights into the treatment of traumatic brain injury (TBI): Acrolein, a natural product isolated from areca nut, promotes neuronal survival and protects from traumatic brain injury via up regulation of its target gene, 26/July/2014, 8.50 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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