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The 1989 Nobel prize winner in Physiology/Medicine, Prof. Bishop JM, Qu J and others from G.W. Hooper Foundation, University of California at San Francisco, San Francisco, California 94143, USA has published a research paper in the 11 June 2012 J Cell Biol (I.F: >10) stating that “Nucleostemin maintains self-renewal of embryonic stem cells and promotes reprogramming of somatic cells to pluripotency.”  

Based on this this finding, Dr Boominathan, Founder Director-cum-chief scientist of GBMD, reports that: Interleukin-based Anti-Cancer Stem cell therapy: Interleukin-1β (IL-1β) suppresses the expression of Nucleoplasmin and reprogramming of somatic cells via down regulation of its target gene.  This study suggests that Interleukin-1β, by suppressing the expression of Nucleoplasmin, it may increase the expression of a number of tumor suppressor genes. Thereby, it may inhibit self-renewal of ESEs. Thus, pharmacological formulations encompassing Interleukin-1β or its activators” may be used to target cancer stem cells and cure human cancer. 

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan, Interleukin-based Anti-Cancer Stem cell therapy: Interleukin-1β (IL-1β) suppresses the expression of Nucleoplasmin and reprogramming of somatic cells via down regulation of its target gene, 9/October/2014, 5.06 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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