A recent study from the Laboratory of Genome Integrity, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA shows that “DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier.” This study was published in the 27 July 2014 issue of Nature by Prof André Nussenzweig, Margarida A. Santos, and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Interleukin-based Differentiation therapy for Human Leukaemia: Interleukin-1β (IL-1β) functions as an anti-cancer barrier by promoting differentiation of leukaemic cells via up regulation of Histone methyl-transferase MLL4. By increasing the expression of IL-1β in myeloid leukaemic cells, one may promote differentiation of leukaemic cells. Together, this study suggests that pharmacological formulations encompassing “IL-1β or its activators” may be used to treat human leukaemia.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Interleukin-based Differentiation therapy for Human Leukaemia: Interleukin-1β (IL-1β) functions as an anti-cancer barrier by promoting differentiation of leukaemic cells via up regulation of Histone methyl-transferase MLL4, 6/October/2014, 4.50 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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