Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Web: http://genomediscovery.org
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To cite: Boominathan, Interleukin-based therapy for Metabolic disorders: Stem cell protein Oct-4 increases insulin sensitivity, restores mucosal immunity and decreases endotoxaemia via up regulation of Interleukin-22 (IL-22), 14/October/2014, 8.51 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Significance: This study suggests, for the first time, that Oct-4, by increasing the expression of IL-22, it may increase insulin sensitivity, restore gut immunity and decrease endotoxaemia. Together, this study suggests that pharmacological formulations encompassing “Oct-4 activators” may be used to treat metabolic disorders, including T2DM and cardiac diseases.