A recent study from the Department of Biology, McGill University, H3A 1B1, Montreal, Quebec, Canada shows that “Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice.“ This study was published in the 15 October 2005 issue of the journal “Genes & Development” (Impact factor: 12.44) by Prof Hekimi S, Liu X, and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Lifespan extension therapy: TCF3 promotes cellular fitness and life span via up regulation of its target gene
Significance:
This study suggests a Lifespan extension therapy. TCF3, by increasing the expression of its target gene, it may decrease the expression of mclk1. Thereby it may: (1) increase cellular fitness; and (2) extend lifespan. Thus, pharmacological formulations encompassing “TCF3 activators or small molecule compounds that activate TCF3 but suppress mclk1“ may be used to increase cellular fitness; and extend lifespan.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Lifespan extension therapy: TCF3 promotes cellular fitness and life span via up regulation of its target gene, 2/May/2015, 22.35, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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