A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ) by Prof Dominic J. Withers, Dr. Selman C and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Massage therapy for Lifespan extension: Massage inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and increases the expression of longevity gene Sirtuin-1 via its target gene, 24/January/2015, 12.20 pm
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, Massage therapy for Lifespan extension: Massage inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and increases the expression of longevity gene Sirtuin-1 via its target gene, 24/January/2015, 12.20 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Significance: It has been shown earlier that massage therapy cures a number of human diseases. However, the mechanistic basis of which remains elusive. This study suggests, for the first time, that massage (moderate pressure–pressure receptor-mechanotransduction), by regulating the expression of its target gene, it may (1) inhibit the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase); and (2) increase the expression of longevity-promoting gene Sirtuin-1. Thereby, it may promote (1) resistance to bone, immune, and motor dysfunction; (2) insulin sensitivity; and (3) brain health. Together, this study provides molecular mechanistic insights into how massage therapy may aid one to extend his/her life span. Thus, Physicians may consider recommending massage therapy to the needy patients.
Undisclosed information: How massage therapy (1) inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase); and (2) increases the expression of longevity-promoting gene Sirtuin-1.