Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Citation: Boominathan, Mechanism of tumorigenesis: Argonaute-2 (Ago2) increases the expression of Notch-1 and -2 via down regulation of its target gene, 27/October/2014, 20.47, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Significance: This study suggests that Argonaute-2 (Ago2), by decreasing the expression of its target gene, it may increase the expression of Notch1 and Notch2. Thus, pharmacological formulations encompassing “Argonaute-2 (Ago2) inhibitor“ may be used to inhibit tumorigenesis and metastasis.
Amount: $300
Undisclosed information: A mechanistic insight into how Argonaute-2 (Ago2) increases the expression of Notch-1 and Notch-2.
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