Mechanistic and Therapeutic insights into Cardiac reprogramming: Interleukin-6 (IL-6) promotes the generation of cardiomyocyte-like cells from differentiated cells by decreasing Snai1/Snail expression, 13/July/2014, 6.13 am

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  • A study from the Department of Clinical and Molecular Cardiovascular Research, Keio University School of Medicine, Shinjuku-ku Tokyo, Japan;  Department of Cardiology, Keio University School of Medicine, Shinjuku-ku Tokyo, Japan;  and  JST CREST, Shinjuku-ku Tokyo, Japan has reported that “MiR-133 promotes cardiac reprogramming by directly repressing Snai1 and silencing …”

  • This study was published in the 11 June 2014 EMBO Journal by Prof. Ieda M, Muraoka N and others from the Department of Clinical and Molecular Cardiovascular Research, Keio University School of Medicine, Shinjuku-ku Tokyo, Japan Department of Cardiology, Keio University School of Medicine, Shinjuku-ku Tokyo, Japan.
  • On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: Mechanistic and Therapeutic insights into Cardiac reprogramming: Interleukin-6 (IL-6) promotes the generation of cardiomyocyte-like cells from differentiated cells by decreasing Snai1/Snail expression. This study suggests that Interleukin-6 (IL-6), by decreasing the expression of its target gene, it could increase the number of beating cardiomyocyte-like cells (iCMs).  Taken together, this study suggests that (1) pharmacological formulations containing “Interleukin-6 (IL-6) or its activator” can be used to increase the number of beating cardiomyocyte-like cells (iCMs); and (2) Interleukin-6 (IL-6) activators  can be used to promote cardiac repair.
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Idea Proposed/Formulated by: Dr L Boominathan Ph.D.

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To cite: Boominathan, Mechanistic and Therapeutic insights into Cardiac reprogramming: Interleukin-6 (IL-6) promotes the generation of cardiomyocyte-like cells from differentiated cells by decreasing Snai1/Snail expression, 13/July/2014, 6.13 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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