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Idea Proposed/Formulated by: Dr L Boominathan Ph.D.

Web: http://genomediscovery.org

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To citeBoominathan, Mechanistic and Therapeutic insights into Cardiac reprogramming: TAp63 promotes the generation of cardiomyocyte-like cells from differentiated cells by decreasing Snai1/Snail expression, 21/October/2014, 8.13 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Significance: This study suggests that TAp63, by increasing the expression of its target gene, it could increase the number of beating cardiomyocyte-like cells (iCMs).  Taken together, this study suggests that (1) pharmacological formulations containing “TAp63 or its activator” can be used to increase the number of beating cardiomyocyte-like cells (iCMs); and (2) TAp63 activators  can be used to promote cardiac repair.

Amount: $ 500

Undisclosed information: A detailed mechanistic insight into how p63 increases the number of beating cardiomyocyte-like cells.

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