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To cite: Boominathan, Mechanistic and Therapeutic insights into Cardiac reprogramming: TAp63 promotes the generation of cardiomyocyte-like cells from differentiated cells by decreasing Snai1/Snail expression, 21/October/2014, 8.13 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Significance: This study suggests that TAp63, by increasing the expression of its target gene, it could increase the number of beating cardiomyocyte-like cells (iCMs). Taken together, this study suggests that (1) pharmacological formulations containing “TAp63 or its activator” can be used to increase the number of beating cardiomyocyte-like cells (iCMs); and (2) TAp63 activators can be used to promote cardiac repair.
Amount: $ 500
Undisclosed information: A detailed mechanistic insight into how p63 increases the number of beating cardiomyocyte-like cells.
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