A recent study from the Division of Infection and Immunity, University College London, London, UK shows that “The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells.” This study was published in the August 24 2014 Nature Immunology by Prof Arne N Akbar, Alessio Lanna and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Mechanistic and therapeutic insights into rejuvenating immune cells in aged people: MiRNA-125b increases telomerase activity and inhibits the senescence of human T cells via down regulation of its target gene. By increasing the expression of MiRNA-125b in immune cells, one may increase telomerase activity and prevent ageing-associated decline in immune function. Together, this study suggests that pharmacological formulations encompassing “miR-125b or miR-125 activators” may be used to inhibit ageing of immune cells.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, L., Mechanistic and therapeutic insights into rejuvenating immune cells in aged people: MiRNA-125b increases telomerase activity and inhibits senescence of human T cells via down regulation of its target gene, 30/August/2014, 06.36 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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