A recent study from the Division of Infection and Immunity, University College London, London, UK shows that “The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells.” This study was published in the August 24 2014 Nature Immunology by Prof Arne N Akbar, Alessio Lanna and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Mechanistic and therapeutic insights into rejuvenating ageing immune cells: Stem cell protein Oct-4 increases telomerase activity and inhibits the senescence of human T cells via up regulation of its target gene. Oct-4, by increasing telomerase activity in immune cells, it may prevent ageing-associated decline in immune function. Together, this study suggests that pharmacological formulations encompassing “Oct-4 or its activator“ may be used to inhibit ageing of immune cells.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, L., Mechanistic and therapeutic insights into rejuvenating ageing immune cells: Stem cell protein Oct-4 increases telomerase activity and inhibits the senescence of human T cells via up regulation of its target gene, 13/September/2014, 07.48 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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