A recent study from the Division of Infection and Immunity, University College London, London, UK shows that “The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells.” This study was published in the August 24 2014 Nature Immunology (The number 1 journal in Immunology with an I.F of 24.973) by Prof Arne N Akbar, Alessio Lanna and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Mechanistic and therapeutic insights into rejuvenating ageing immune cells: Stress-induced gene product p53 decreases telomerase activity and promotes the senescence of human T cells via up regulation of its target gene. p53, by decreasing telomerase activity in immune cells, it may accelerate ageing-associated decline in immune function. Together, this study suggests that pharmacological formulations encompassing “p53 inhibitor” may be used to inhibit ageing of immune cells.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, L., Mechanistic and therapeutic insights into rejuvenating ageing immune cells: Stress-induced gene product p53 decreases telomerase activity and promotes the senescence of human T cells via up regulation of its target gene, 09/September/2014, 14.38, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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