Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Web: http://genomediscovery.org
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To cite: Boominathan, Mechanistic and Therapeutic insights into Vascular endothelial senescence and Arterial stiffness: MiRNA-132 inhibits endotheilial function and increases arterial stiffness via down regulation of its target gene, 15/October/2014, 7.55 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Significance: This study suggests that stress-induced MiRNA-132, by suppressing the expression of its target gene, may promote Vascular endothelial senescence; and Arterial stiffness. Together, pharmacological formulations encompassing “MiRNA-132 inhibitors” may be used to treat endothelial dysfunction and arterial stiffness.