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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, Mechanistic insight into Metastasis progression: IL-17 increases the expression of Zeb2, an epithelial to mesenchymal transition (EMT) promoter, via down regulation of its target gene, 09/February/2015, 22.31, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Significance: This study suggests that IL-17, by decreasing the expression of its target gene, it may increase the expression of Zeb2.  Thereby, it may promote epithelial to mesenchymal transition (EMT) and metastasis. Thus, pharmacological formulations encompassing “IL-17 inhibitors  may be used to inhibit the progression of tumors.

Amount: $ 300

Undisclosed information: How IL-17 increases the expression of Zeb2

Web: http://genomediscovery.org

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