Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Citation: Boominathan, Mechanistic insight into Regulation of Ribosome biogenesis: NR2F2 suppresses the expression of RNA polymerase I via down regulation of its target gene, 22/February/2015, 16.24, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Significance: This study suggests, for the first time, that tumor suppressor NR2F2, by increasing the expression of its target gene, it may decrease the expression of RNA polymerase I. Thereby, it may inhibit the proliferation of cancer cells. Thus, pharmacological formulations encompassing “NR2F2 activators” can be used to inhibit the progression of human cancers.
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* Research cooperation
Undisclosed information: How NR2F2 suppresses the expression of RNA polymerase I
Amount: $ 300