Significance: This study suggests, for the first time, that TAp63, by increasing the expression of its target gene, it may phosphorylate tumor suppressor p53 (on Ser15). Thereby, it may regulate its ability to transactivate its target genes.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Mechanistic insight into tumor suppression: TAp63 promotes phosphorylation of tumor suppressor p53 (on Ser15) and via up regulation of its target gene, 28/March/2015, 9.39 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Undisclosed information: How TAp63 promotes phosphorylation of tumor suppressor p53 (on Ser15)