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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, Mechanistic insight into tumorigenesis: Orphan Nuclear receptor NUR77 increases the expression of c-Myc via up regulation of its target gene, 4/May/2015, 22.52, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Significance: This study suggests, for the first time, that NUR77, by increasing the expression of its target gene, it may increase the expression of c-Myc. Thereby, it may decrease (1) the expression of tumor suppressor p53; and (2) promote tumorigensis.  Thus, pharmacological formulations encompassing “NUR77 inhibitors”  can be used to inhibit tumor progresssion.

Undisclosed information: How NUR77  increases the expression of proto-oncogene c-Myc

Web: http://genomediscovery.org

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