Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, Mechanistic insight into tumorigenesis: Orphan Nuclear receptor NUR77 increases the expression of MDM2, a negative regulator of stress responsive protein p53, via up regulation of its target gene, 24/April/2015, 21.43, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Significance: This study suggests, for the first time, that NUR77, by increasing the expression of its target gene, it may increase the expression of E3 ubiquitin ligase MDAM2. Thereby, it may decrease (1) the expression of tumor suppressor p53; and (2) promote tumorigensis. Thus, pharmacological formulations encompassing “NUR77 inhibitors” can be used to inhibit tumor progresssion.
Undisclosed information: How NUR77 decreases the expression of MDM2
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