Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Citation: Boominathan, Mechanistic insight into tumorsuppression: BMP-6 increases the expression of tumor suppressor p53 homologue p73 via up regulation of its target gene, 09/February/2015, 21.14, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Significance: This study suggests, for the first time, that BMP-6, by increasing the expression of its target gene, it may increase the expression of TAp73, promote senescence, and inhibit the expression of cancer stem cell genes. Given that tumor suppressor p53 is mutated in more than 50% of different human cancers, this study suggests, for the first time, a therapeutic strategy as to how mutant p53 expressing human cancers can be cured; That is, by activating its un-mutated homologous proteins, such as p73. Thus, pharmacological formulations encompassing “BMP-6 or its activators” may be used to inhibit the progression of human tumors, including p53-mutated human tumors.
Amount: $ 500*
Undisclosed information: How BMP-6 increases the stability and activity of p73α
Web: http://genomediscovery.org
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* Research cooperation