Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Web: http://genomediscovery.org
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To cite: Boominathan, Mechanistic insights into tumor suppression: SMAD7 increases the expression of tumor suppressor TPM1 via down regulation of its target gene, 17/September/2014, 05.40 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Significance: This study suggests that SMAD7, by decreasing the expression of its target miRNA, it may increase the expression of TPM1. Thereby, it may inhibit invasion and metastatic property of tumor cells. Thus, pharmacological formulations encompassing “SMAD7 activators” may used to treat metastatic cancers.