Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, L., Mechanistic insights into tumorigenesis: MiRNA-92b suppresses the expression of tumor suppressor p53 via down regulation of its target gene, 12/September/2014, 16.45, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Significance: This study suggests, for the first time, that miR-92 inhibits the expression of tumor suppressor p53. It has earlier been shown that miR-92 suppresses the expression of p53 homologue p63. Thus, pharmacological formulations encompassing “antagomiR-92” may be used to inhibit cancer progression.