A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the March 7 2013 Nature by Prof Dimmler, Boon, and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Mechanistic & Therapeutic insights into how stress promotes cardiac ageing: Prolonged induction of Adenocarticotrophic hormone (ACTH) inhibits myocardial function and promotes myocardial infarction via up regulation of its target gene. By decreasing the expression of ACTH, or normalizing the levels of ACTH, one may prevent ageing/stress-associated decline in cardiac function. Together, this study suggests that pharmacological formulations encompassing“ACTH inhibitors or ACTH-induced target gene inhibitors” may be used to improve cardiac function after myocardial infarction.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, Mechanistic & Therapeutic insights into how stress promotes cardiac ageing: Prolonged induction of Adenocarticotrophic hormone (ACTH) inhibits myocardial function and promotes myocardial infarction via up regulation of its target gene, 18/August/2014, 08.04, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Significance: This study elucidates the mechanism by which Stress-induced ACTH declines myocardial function. Furthermore, this study suggests, for the first time, ACTH inhibitors can be used to treat patients suffering from various myocardial disorders, including myocardial infarction.
