- A study from the Departments of Anesthesiology and Neurobiology, Duke University Medical Center, Durham, NC 27710, USA has reported that “Extracellular MicroRNAs Activate Nociceptor Neurons to Elicit Pain via….”
- This study was published in the 02 April 2014 Neuron by Prof. Ji RR, Park CK and others from the Departments of Anesthesiology and Neurobiology, Duke University Medical Center, Durham, NC 27710, USA.
- On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: Mechanistic & Therapeutic insights into pain responses: Tumor suppressor p53 aggravates pain responses via up regulation of cation channel transient receptor potential A1. This study suggests that stress-responsive protein p53, by increasing the expression of its target gene, it could aggravate pain responses. Together, this study suggests that pharmacological formulations containing “p53 inhibitors” can be used to alleviate pain responses.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Mechanistic & Therapeutic insights into pain responses: Tumor suppressor p53 aggravates pain responses via up regulation of cation channel transient receptor potential A1, 12/June/2014, 5,30 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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