Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Citation: Boominathan, Natural product-based therapy for Metastatic tumors: Cucurbitacin I (JSI-124) suppresses the expression of PD-1, a suppressor of activation of T-cells, and activates the immune system via down regulation of its target gene, 23/February/2015, 22.49, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Significance: It has recently been shown that blocking PD-1 with antibodies, one could make tumors shrink. This study suggests, for the first time, that Cucurbitacin I by suppressing the expression of its target gene, it may decrease the expression of PD-1. Thereby, it may activate the immune system to inhibit tumor progression. Thus, pharmacological formulations encompassing “Cucurbitacin I or its analogues“ may be used to inhibit the progression of tumors.
Amount: $ 500*
Undisclosed information: How Cucurbitacin I suppresses the expression of PD-1
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