A study from the Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA shows that “ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signalling.”
This study was published in the September issue of 2014 Nature Cell Biology (I.F: 20.085) by Dr. Kang Y, Rumela Chakrabarti [I.F > 20.058] and others from the Princeton University, New Jersey 08544, USA
On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: MiRNA-based Anti-cancer stem cell therapeutics: MiRNA-92 inhibits mammary cancer stem cell proliferation via down regulation of Wnt receptor FZD7. This study may suggest that MiRNA-92, by down regulating its target gene, it may inhibit the Wnt pathway. Together, this study suggests that pharmacological formulations encompassing “MiRNA-92 or its activators” can be used to inhibit tumor initiating mammary cancer cells.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, L., MiRNA-based Anti-cancer stem cell therapeutics: MiRNA-92 inhibits mammary cancer stem cell proliferation via down regulation of Wnt receptor FZD7, 03/October/2014, 10.53 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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