The 1989 Nobel prize winner in Physiology/Medicine, Prof. Bishop JM, Qu J and others from G.W. Hooper Foundation, University of California at San Francisco, San Francisco, California 94143, USA has published a research paper in the 11 June 2012 J Cell Biol (I.F: >10) stating that “Nucleostemin maintains self-renewal of embryonic stem cells and promotes reprogramming of somatic cells to pluripotency.”
Based on this this finding, Dr Boominathan, Founder Director-cum-chief scientist of GBMD, reports that: MiRNA-based Anti-Cancer stem cell therapy: MiRNA-127 inhibits the expression of Nucleostemin and reprogramming of somatic cells via up regulation of its target genes. This study suggests that MiRNA-127, by suppressing the expression of Nucleoplasmin, it may increase the expression of a number of tumor suppressor genes. Thereby, it may inhibit self-renewal of ESEs. Thus, pharmacological formulations encompassing “MiRNA-127 or its activators” may be used to target cancer stem cells and cure human cancer.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, MiRNA-based Anti-Cancer stem cell therapy: MiRNA-127 inhibits the expression of Nucleostemin and reprogramming of somatic cells via up regulation of its target genes, 6/October/2014, 7.59 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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