Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Citation: Boominathan, MiRNA-based anti-cancer stem cell therapy: Tumor suppressor p53 suppresses the expression SALL4, a transcriptional activator of Oct-4, via down regulation of its target gene, 8/February/20145, 22.48, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Significance: This study suggests, for the first time, that p53, by increasing the expression of its target gene, it may inhibit the expression of SALL4. Thereby, it may inhibit the migration and invasion of cancer cells. Thus, pharmacological formulations encompassing “p53 or its activators” can be used to inhibit the proliferation of cancer stem cells.
Amount: $ 300
Undisclosed information: How p53 suppresses the expression of SALL4
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