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Significance: This study suggests, for the first time, that HMGB1, by increasing the expression of its target gene, it may: (1) decrease the expression of gluconeogenesis genes, such as PEPCK and G6Pase; (2) reduce hepatic glucose production; (3) improve muscle insulin sensitivity; (4) decrease white adipose tissue mass and adiposisty; and (5) mimick the positive effects of exercise. Thus, pharmacological formulations encompassing “HMGA1 activators” may be used to inhibit insulin resistance, decrease adiposity, and treat T2DM.

Undisclosed information: How HMGB1 mimicks the effects of exercise and promotes insulin sensitivity and decreases adiposity

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan, The Exercise-Mimicking pills may inhibit Insulin resistance and decrease adiposity: HMGB1 decreases gluconeogenesis genes, such as PEPCK and G6Pase, reduces hepatic glucose production, improves muscle insulin sensivitity and decreases adiposity via up regulation of its target gene, 27/April/2015,  8.01 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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