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Significance: This study suggests, for the first time, that MiRNA-582-5p, by decreasing the expression of its target gene, it may: (1) decrease the expression of gluconeogenesis genes, such as PEPCK and G6Pase; (2) reduce hepatic glucose production; (3) improve insulin sensitivity; and (4) mimick the effects of exercise. Thus, pharmacological formulations encompassing “MiRNA-582-5p activators” may be used to inhibit insulin resistance and treat T2DM.

Undisclosed information: How MiRNA-582-5p mimicks the effects of exercise and promotes insulin sensitivity

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan, MiRNA-based Exercise-Mimicking pill may inhibit Insulin resistance: MiRNA-582-5p decreases gluconeogenesis genes, such as PEPCK and G6Pase, reduces hepatic glucose production, and improves insulin sensivitity via down regulation of its target gene, 25/April/2015,  22.05,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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