A recent study from the Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection.” This study was published in the 2 March 2015 issue of the Journal “Nature Immunology”[I.F: 24.973] by Drs. Zusen Fan, Xia and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: MiRNA-based Immune enhancement therapy: Lin-28 increases SOX2 expression and promotes innate immunity against bacterial infection via down regulation of its target gene. This study suggests, for the first time, Lin-28, by decreasing the expression of its target gene, it may : (1) increase the expression of Sox2; (2) increase the ability of Sox2 to recognize bacterial DNA in cytoplasm; and (3) promote innate immunity against bacterial infection. Together, pharmacological formulations encompassing “Lin-28 activators” may be used to (1) enhance innate immunity against bacterial infection; and (2) promote bacterial resistance.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, MiRNA-based Immune enhancement therapy: Lin-28 increases SOX2 expression and promotes innate immunity against bacterial infection via down regulation of its target gene, 08/March/2015, 16.47, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Undisclosed information: How Lin-28 (1) enhances innate immunity against bacterial infection; and (2) promotes bacterial resistance.
