A recent study from the Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection.” This study was published in the 2 March 2015 issue of the Journal “Nature Immunology”[I.F: 24.973] by Drs. Zusen Fan, Xia and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: MiRNA-based Immune enhancement therapy: NRF2 increases SOX2 expression and promotes innate immunity against bacterial infection via down regulation of its target gene. This study suggests, for the first time, NRF2, by decreasing the expression of its target gene, it may : (1) increase the expression of Sox2; (2) increase the ability of Sox2 to recognize bacterial DNA in cytoplasm; and (3) promote innate immunity against bacterial infection. Together, pharmacological formulations encompassing “NRF2 activators” may be used to (1) enhance innate immunity against bacterial infection; and (2) promote bacterial resistance.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, MiRNA-based Immune enhancement therapy: NRF2/NFE2L2 increases SOX2 expression and promotes innate immunity against bacterial infection via down regulation of its target gene, 09/March/2015, 06.05 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Undisclosed information: How NRF2 (1) increases the expression of Sox2; and (2) promotes bacterial resistance.