Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, L., MiRNA-based Lifespan extension therapy: MiRNA-25 prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 2/June/2014, 10.25 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Significance: It has been shown earlier that angiotensin II type I receptor (AT1R) antagonist prolongs mammalian life span. This study suggests, for the first time, that MiRNA-25 , by decreasing the expression of its target gene, it may suppress the expression of AT1R. And, thereby, it may (1) decrease blood pressure; and (2) and extend the lifespan of an individual. Thus, pharmacological formulations encompassing “MiRNA-25 activators“ may be used to extend the life-span of an individual.
Undisclosed information: How MiRNA-25 suppresses the expression of angiotensin II type I receptor (AT1R)