A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March 2013 issue of Nature by Prof Dimmler, Boon, and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: MiRNA-based Regenerative Stem cell therapy for Myocardial Infarction: MiRNA-3473b improves ageing- and stress-associated decline in cardiac function via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10). By treating aged people who are susceptible to cardiac diseases with miRNA-3473b activators, one may prevent ageing-associated decline in cardiac function. Together, this study suggests that pharmacological formulations encompassing “miR-3473b activators” may be used to improve cardiac function after myocardial infarction.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Undisclosed information: How miR-3473b increases the expression of PNUTS/PPP1R10
To cite: Boominathan, MiRNA-based Regenerative Stem cell therapy for Myocardial Infarction: MiRNA-3473b improves ageing- and stress-associated decline in cardiac function via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 4/February/2015, 22.17, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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