Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, MiRNA-based Regenerative therapy for DM: Zinc finger protein Slug/SNAI2 increases insulin-secreting cell mass and function via down regulation of its target genes, 8/March/2015, 23.19, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Significance: This study suggests, for the first time, that Slug, by decreasing the expression of its target gene, it may increase insulin-secreting cell mass and function. Thereby, it may increase the insulin sensitivity of cellular tissues. Thus, pharmacological formulations encompassing “Slug/SNAI2 or its activators” can be used to treat DM.
Undisclosed information: How Slug/SNAI2 increases insulin-secreting cell mass and function.
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